Many researchers experiment with participatory settings to increase public engagement in research and innovation (R&I). Because of their temporary nature, it often remains unclear how such participatory experiments can contribute to structural change. This paper empirically explores options for bridging this gap. It analyzes how participants can be supported to act as institutional entrepreneurs to actively promote public engagement in R&I. To draw lessons, we analyze empirical material gathered on nineteen Social Labs which were set up to promote the uptake (...) of Responsible Research and Innovation in a European R&I funding program (Horizon 2020). Involvement of motivated participants, insight in their institutional context, and specific methods and management choices that enhance a sense of agency are identified as essential for organizing change. These findings and the resulting framework of interventions may prove valuable for further (action) research into the institutionalization of public engagement in R&I. (shrink)

In this paper, I contend that Brandom’s interpretive oversights leave his inferentialist program vulnerable to Hegelian critique. My target is Brandom’s notion of “conceptual realism,” or the thesis that the structure of mind-independent reality mimics the structure of thought. I show, first, that the conceptual realism at the heart of Brandom’s empiricism finds root in his interpretation of Hegel. I then argue that conceptual realism is incompatible with Hegel’s thought, since the Jena Phenomenology, understood as a “way of despair,” includes (...) a critique of the philosophical framework upon which conceptual realism relies. Finally, I offer the Hegelian critique of Brandom that results from these textual infidelities. (shrink)

In the Euthydemus, Socrates is presented as an eager student of seemingly trivial arts, earning derision both for desiring to master the peculiar art of Euthydemus and Dionysodorus and for studying the harp in his old age. I explain Socrates’ interest in these apparently trivial arts by way of a novel reading of the first protreptic argument, suggesting that the wisdom Socrates praises is complex in nature, securing the happiness of its possessor only insofar as it is composed of both (...) ordinary productive knowledge and ethically productive knowledge. This reading of the first protreptic makes sense of the otherwise perplexing second protreptic, explaining why Socrates is so keen to identify an art which makes what it uses. Wisdom acts as a reliable source of benefit only insofar as it is a complex composed of multiple different arts and types of knowledge. These arts, however, can only be acquired one at a time – if no single art is capable of combining the powers of both ordinary productive knowledge and ethically productive knowledge in the way that wisdom as a whole does, then the pursuit of wisdom will fail to offer reliable benefit despite the reliably beneficial nature of its possession. Thus, it is appropriate for the Euthydemus to conclude with Socrates telling Crito to take courage and pursue philosophy despite the seemingly harmful effects that its pursuit has had on others. Euthydemus and Dionysodorus represent the danger facing the aspiring philosopher, the possibility of being ruined by independent possession of the particular kind of ordinary productive knowledge on which philosophical activity depends – verbal mastery, the grasp of subtle conceptual distinctions needed both to argumentatively reveal reality and to argumentatively obscure it, to reliably equivocate and to reliably avoid equivocation. (shrink)

Plato's 'Republic' constructs an ideal city composed of three parts, parallel to the soul's reason, appetites, and fighting spirit. But confusion and controversy have long surrounded this three-way division and especially the prominent role it assigns to angry and competitive spirit. In Plato's Three-fold City and Soul, Joshua I. Weinstein argues that, for Plato, determination and fortitude are not just expressions of our passionate or emotional natures, but also play an essential role in the rational agency of persons and (...) polities. In the Republic's account, human life requires spirited courage as much as reasoned thought and nutritious food. The discussion ranges over Plato's explication of the logical and metaphysical foundations of justice and injustice, the failures of incomplete and dysfunctional cities, and the productive synergy of our tendencies and capacities that becomes fully evident only in the justice of a self-sufficient political community. (shrink)

American psychologist and pragmatist philosopher James (1842- 1910) is generally considered too individualistic to have had any interest in politics, but Miller argues that political concerns were in fact central to his intellectual work. He finds in James a theorist of action, explores the complexities of his theory, and related his thought to Miller's own experience as a political activist and scholar. Annotation copyrighted by Book News, Inc., Portland, OR.

_ Source: _Volume 23, Issue 2, pp 161 - 195 The Greek tradition of political philosophy, with its prominent focus on the forms of government, should be distinguished from the discourse typical of many rabbinic sources, with its concern for collective goals. This discourse commonly deploys broad, mid-level goals to mediate between abstract theology and practical law. Among these goals, yishuv medinah focuses on the economic and social development of a region or district, articulating the character of local needs. This (...) is compared to related goals—the settling of the world and the ordering of the world —and contrasted with Aristotle’s approach, which in many ways typifies the Greek tradition. (shrink)

Legal inference is fundamental for building and verifying hypotheses in police investigations. In this study, we build a Natural Language Inference dataset in Korean for the legal domain, focusing on criminal court verdicts. We developed an adversarial hypothesis collection tool that can challenge the annotators and give us a deep understanding of the data, and a hypothesis network construction tool with visualized graphs to show a use case scenario of the developed model. The data is augmented using a combination of (...) Easy Data Augmentation approaches and round-trip translation, as crowd-sourcing might not be an option for datasets with sensible data. We extensively discuss challenges we have encountered, such as the annotator’s limited domain knowledge, issues in the data augmentation process, problems with handling long contexts and suggest possible solutions to the issues. Our work shows that creating legal inference datasets with limited resources is feasible and proposes further research in this area. (shrink)

BackgroundAn increasing number of studies utilize intracranial electrophysiology in human subjects to advance basic neuroscience knowledge. However, the use of neurosurgical patients as human research subjects raises important ethical considerations, particularly regarding informed consent and undue influence, as well as subjects’ motivations for participation. Yet a thorough empirical examination of these issues in a participant population has been lacking. The present study therefore aimed to empirically investigate ethical concerns regarding informed consent and voluntariness in Parkinson’s disease patients undergoing deep brain (...) stimulator (DBS) placement who participated in an intraoperative neuroscience study.MethodsTwo semi-structured 30-minute interviews were conducted preoperatively and postoperatively via telephone. Interviews assessed participants’ motivations for participation in the parent intraoperative study, recall of information presented during the informed consent process, and participants’ postoperative reflections on the research study.ResultsTwenty-two participants (mean age = 60.9) completed preoperative interviews at a mean of 7.8 days following informed consent and a mean of 5.2 days prior to DBS surgery. Twenty participants completed postoperative interviews at a mean of 5 weeks following surgery. All participants cited altruism or advancing medical science as “very important” or “important” in their decision to participate in the study. Only 22.7% (n = 5) correctly recalled one of the two risks of the study. Correct recall of other aspects of the informed consent was poor (36.4% for study purpose; 50.0% for study protocol; 36.4% for study benefits). All correctly understood that the study would not confer a direct therapeutic benefit to them.ConclusionEven though research coordinators were properly trained and the informed consent was administered according to protocol, participants demonstrated poor retention of study information. While intraoperative studies that aim to advance neuroscience knowledge represent a unique opportunity to gain fundamental scientific knowledge, improved standards for the informed consent process can help facilitate their ethical implementation. (shrink)

Commentary about the role of AI in bioethics for the 10th anniversary issue of AJOB: Empirical Bioethics.

This article offers a series of critical theorizations on the biopolitical dimensions of methicillin-resistant Staphylococcus aureus (MRSA), with specific attention to what has recently been referred to in the United States as the ‘MRSA Epidemic’. In particular, we reflect on the proliferation of biomedical discourses around the ‘spread’, and the pathogenic potentialities, of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). We turn to the work of Roberto Esposito and Jean-Luc Nancy to better make sense of how, during this immunological crisis, the individualized (...) fleshy and fluid body is articulated to dimensions of community and corporeal proximity; the body is thus conceived in popular biopolitical framings as a site of transmission, inoculation, and isolation – as a living ecological and pathological vessel. We give emphasis to the spatial relations of flesh, namely in how biomedical ‘experts’ have sought to (bio-)technologize spaces of heightened communal bodily contact (such as playgrounds or gymnasia). (shrink)

We chart how neuroscience and philosophy have together advanced our understanding of moral judgment with implications for when it goes well or poorly. The field initially focused on brain areas associated with reason versus emotion in the moral evaluations of sacrificial dilemmas. But new threads of research have studied a wider range of moral evaluations and how they relate to models of brain development and learning. By weaving these threads together, we are developing a better understanding of the neurobiology of (...) moral judgment in adulthood and to some extent in childhood and adolescence. Combined with rigorous evidence from psychology and careful philosophical analysis, neuroscientific evidence can even help shed light on the extent of moral knowledge and on ways to promote healthy moral development. (shrink)

Ageing is associated with a decline in autophagy and elevated reactive oxygen species (ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can cause further cellular damage, including DNA breaks and protein misfolding. This poses a challenge for longevous organisms, including humans. In this review, we hypothesise that in the course of human evolution selective autophagy receptors (SARs) acquired the ability to sense and respond to localised oxidative stress. We posit that in the vicinity of protein aggregates (...) and dysfunctional mitochondria oxidation of key cysteine residues in SARs induces their oligomerisation which initiates autophagy. The degradation of damaged cellular components thus could reduce ROS production and restore redox homeostasis. This evolutionarily acquired function of SARs may represent one of the biological adaptations that contributed to longer lifespan. Inversely, loss of this mechanism can lead to age‐related diseases associated with impaired autophagy and oxidative stress. (shrink)

Responsible Research and Innovation (RRI) has only lately included environmental sustainability as a key area for the social desirability of research and innovation. That is one of the reasons why just a few RRI projects and proposals include environmental sustainability, and Climate Change (CC) in particular. CC is one of the grand challenges of our time and, thus, this paper contributes to the operationalization of CC prevention in RRI. To this end, the tools employed against CC were identified. Tools originated (...) in corporate social responsibility and sustainable innovation which help to operationalize strategies against CC in RRI practice. Complementarily, the latest proposals by RRI projects and actors related to CC were reviewed. The findings of the document analysis and the web review were arranged in a framework intended for research and innovation that has an indirect but relevant negative impact due to CC. Thus, four main strategies for CC prevention in RRI were determined: a voluntary integration of the aims, a life cycle perspective, open access databases and key performance indicators, and stakeholder management. The article is finished acknowledging diverse barriers hindering the operationalization of CC prevention in RRI, and we introduce future avenues for research in this area. (shrink)

Concordance of the poetic works of Giorgos Seferis which presents all the principal “words” of the texts in an alphabetical list, stating how often each word occurs, giving a precise location and a relevant piece of text for each occurrence. We found ca. 9500 different Greek words in 39000 different occurrences, so our concordance has 50.000 lines of text. The technical procedure required four main steps: text entry and tagging, production of the concordance, correction of the contexts, formatting for print.

The YAP/TAZ family of transcriptional co‐activators drives cell proliferation in epithelial tissues and cancers. Yet, how YAP and TAZ are physiologically regulated remains unclear. Here we review recent reports that YAP and TAZ act primarily as sensors of epithelial cell polarity, being inhibited when cells differentiate an apical membrane domain, and being activated when cells contact the extracellular matrix via their basal membrane domain. Apical signalling occurs via the canonical Crumbs/CRB‐Hippo/MST‐Warts/LATS kinase cascade to phosphorylate and inhibit YAP/TAZ. Basal signalling occurs (...) via Integrins and Src family kinases to phosphorylate and activate YAP/TAZ. Thus, YAP/TAZ is localised to the nucleus in basal stem/progenitor cells and cytoplasm in differentiated squamous cells or columnar cells. In addition, other signals such as mechanical forces, tissue damage and possibly receptor tyrosine kinases (RTKs) can influence MST‐LATS or Src family kinase activity to modulate YAP/TAZ activity. (shrink)

Artificial intelligence (AI) and robotics are digital technologies that will have significant impact on the development of humanity in the near future. They have raised fundamental questions about what we should do with these systems, what the systems themselves should do, what risks they involve, and how we can control these. - After the Introduction to the field (§1), the main themes (§2) of this article are: Ethical issues that arise with AI systems as objects, i.e., tools made and used (...) by humans. This includes issues of privacy (§2.1) and manipulation (§2.2), opacity (§2.3) and bias (§2.4), human-robot interaction (§2.5), employment (§2.6), and the effects of autonomy (§2.7). Then AI systems as subjects, i.e., ethics for the AI systems themselves in machine ethics (§2.8) and artificial moral agency (§2.9). Finally, the problem of a possible future AI superintelligence leading to a “singularity” (§2.10). We close with a remark on the vision of AI (§3). - For each section within these themes, we provide a general explanation of the ethical issues, outline existing positions and arguments, then analyse how these play out with current technologies and finally, what policy consequences may be drawn. (shrink)

Our beliefs about which actions we ought to perform clearly have an effect on what we do. But so-called “Humean” theories—holding that all motivation has its source in desire—insist on connecting such beliefs with an antecedent motive. Rationalists, on the other hand, allow normative beliefs a more independent role. I argue in favor of the rationalist view in two stages. First, I show that the Humean theory rules out some of the ways we ordinarily explain actions. This shifts the burden (...) of proof onto Humeans to motivate their more restrictive, revisionary account. Second, I show that they are unlikely to discharge this burden because the key arguments in favor of the Humean theory fail. I focus on some of the most potent and most recent lines of argument, which appeal to either parsimony, the teleological nature of motivation, or the structure of practical reasoning. (shrink)

Epistemic trespassing, science denial, refusal to guard against bias, mishandling higher-order evidence, and the development of vice are troubling intellectual behaviors. In this paper, I advance work done by psychologists on moral self-licensing to show how all of these behaviors can be explained in terms of a parallel phenomenon of epistemic self-licensing. The paper situates this discussion at the intersection of three major epistemological projects: epistemic explanation and intervention (the project of explaining troubling intellectual phenomena in the hopes of deriving (...) ameliorative strategies), hostile epistemology (the study of how intellectual vulnerabilities might be exploited), and the promise of higher- order evidence (the hope that higher-order evidence leads to epistemic improvement). Analyzing epistemic licensing allows us to explain and offer modest interventions aimed at mitigating these behaviors, while illuminating exploitable vulnerabilities and tempering optimism about the promise of higher-order evidence. -/- . (shrink)

Virtue ethics has been dogged by the objection that it lacks the ability to provide adequate action-guidance, that it is agent-centered rather act-centered. Virtue ethics has also been faulted for devolving into moral cultural relativism. Rosalind Hursthouse has presented an action-based, naturalistic theory of virtue ethics intended to defuse these charges. Despite its merits, I argue that Hurthouse’s theory fails to successfully solve the problems associated with action guidance and relativism precisely because her attempt to provide a non-cultural basis for (...) virtue ethics undermines the possibility of using virtue ethics to derive useful action-guidance. The action-guiding power of virtue is derived from culture; seeking to avoid the cultural grounding of virtue merely brings one back to the problem of how virtue ethics can provide action-guidance. (shrink)

There are many domains about which we think we are reliable. When there is prima facie reason to believe that there is no satisfying explanation of our reliability about a domain given our background views about the world, this generates a challenge to our reliability about the domain or to our background views. This is what is often called the reliability challenge for the domain. In previous work, I discussed the reliability challenges for logic and for deductive inference. I argued (...) for four main claims: First, there are reliability challenges for logic and for deduction. Second, these reliability challenges cannot be answered merely by providing an explanation of how it is that we have the logical beliefs and employ the deductive rules that we do. Third, we can explain our reliability about logic by appealing to our reliability about deduction. Fourth, there is a good prospect for providing an evolutionary explanation of the reliability of our deductive reasoning. In recent years, a number of arguments have appeared in the literature that can be applied against one or more of these four theses. In this paper, I respond to some of these arguments. In particular, I discuss arguments by Paul Horwich, Jack Woods, Dan Baras, Justin Clarke-Doane, and Hartry Field. (shrink)

Consciousness-based approaches to non-human moral status maintain that consciousness is necessary for (some degree or level of) moral status. While these approaches are intuitive to many, in this paper I argue that the judgment that consciousness is necessary for moral status is not secure enough to guide policy regarding non-humans, that policies responsive to the moral status of non-humans should take seriously the possibility that psychological features independent of consciousness are sufficient for moral status. Further, I illustrate some practical consequences (...) of calling consciousness-based views into question. (shrink)

The extensive involvement of nonconscious processes in human behaviour has led some to suggest that consciousness is much less important for the control of action than we might think. In this article I push against this trend, developing an understanding of conscious control that is sensitive to our best models of overt action control. Further, I assess the cogency of various zombie challenges—challenges that seek to demote the importance of conscious control for human agency. I argue that though nonconscious contributions (...) to action control are evidently robust, these challenges are overblown. (shrink)

How should we understand validity? A standard way to characterize validity is in terms of the preservation of truth (or truth in a model). But there are several problems facing such characterizations. An alternative approach is to characterize validity epistemically, for instance in terms of the preservation of an epistemic status. In this paper, I raise a problem for such views. First, I argue that if the relevant epistemic status is factive, such as being in a position to know or (...) having conclusive evidence for, then the account runs into trouble if we endorse certain familiar logical principles. Second, I argue that if the relevant epistemic status is non-factive, such as is rationally committed to or has justification for believing, then a similar problem arises if we endorse the logical principles as well as a sufficiently strong epistemic “level-bridging” principle. Finally, I argue that an analogous problem arises for the most natural characterization of validity in terms of rational credence. (shrink)

This chapter discusses epistemic objections to non-naturalist moral realism. The goal of the chapter is to determine which objections are pressing and which objections can safely be dismissed. The chapter examines five families of objections: (i) one involving necessary conditions on knowledge, (ii) one involving the idea that the causal history of our moral beliefs reflects the significant impact of irrelevant influences, (iii) one relying on the idea that moral truths do not play a role in explaining our moral beliefs, (...) (iv) one involving the claim that if moral realism is true then our moral beliefs are unlikely to be reliable, and (v) one involving the claim that moral realism is incompatible with there being a plausible explanation of our reliability about morality. The overall conclusion of the chapter is that the final objection is by far the most pressing. (shrink)

I argue for the existence of imaginative beliefs: mental states that are imaginative in format and doxastic in attitude. I advance two arguments for this thesis. First, there are imaginings that play the functional roles of belief. Second, there are imaginings that play the epistemic roles of belief. These arguments supply both descriptive and normative grounds for positing imaginative beliefs. I also argue that this view fares better than alternatives that posit distinct imaginative and doxastic states to account for the (...) same phenomena. Along the way, I demonstrate the theoretical significance of imaginative beliefs by showing how they pose a challenge for standard taxonomies of the mind, clarify the sense in which imagination is occurrent and voluntary, explain the justificatory role of the imagination, and point to a deep but underappreciated symmetry between imagistic and non-imagistic thought. (shrink)

Modal Arguments in the philosophy of mind purport to show that the body is not necessary for a human person’s existence. The key premise in these arguments are generally supported with thought experiments. I argue that Christians endorsing the Doctrine of the Resurrection have good reason to deny this key premise. Traditional Christianity affirms that eschatological human existence is an embodied existence in the very bodies we inhabited while alive. The raises the Resurrection Question: why would God go through the (...) trouble of resurrecting those bodies? I argue that adequately answering this question requires give up on Modal Arguments within the philosophy of mind. (shrink)

Background: Informed consent in clinical research is mandated throughout the world. Both patient subjects and investigators are required to understand and accept the distinction between research and treatment.Aim: To document the extent and to identify factors associated with therapeutic misconception in a population of patient subjects or parent proxies recruited from a variety of multicentre trials .Patients and methods: The study comprised two phases: the development of a questionnaire to assess the quality of informed consent and a survey of patient (...) subjects based on this questionnaire.Results: A total of 303 patient subjects or parent proxies were contacted and 279 questionnaires were analysed. The median age was 49.5 years, sex ratio was 1 and 61% of respondents were professionally active. Overall memorisation of the oral or written communication of informed consent was good , and satisfaction with the process was around 70%. Therapeutic misconception was present in 70% of respondents, who expected to receive better care and ignored the consequence of randomisation and treatment comparisons. This was positively associated with the acuteness and severity of the disease.Conclusion: The authors suggest that the risk of therapeutic misconception be specifically addressed in consent forms as an educational tool for both patients and investigators. (shrink)

This chapter contains sections titled: Y, E10+, G, Y7, eC, E, PG? The Causal Hypothesis: Baby See, Baby Do The Edification Hypothesis: I Learned Something Good from Watching Something Bad The Catharsis Hypothesis: I'm So Mad I Should Pretend To Kill You Conclusion: The Decision, Like Fatherhood, is Full of Ambiguities Notes.

The vividness of mental imagery is epistemically relevant. Intuitively, vivid and intense memories are epistemically better than weak and hazy memories, and using a clear and precise mental image in the service of spatial reasoning is epistemically better than using a blurry and imprecise mental image. But how is vividness epistemically relevant? I argue that vividness is higher-order evidence about one’s epistemic state, rather than first-order evidence about the world. More specifically, the vividness of a mental image is higher-order evidence (...) about the amount of first-order information one has about its subject matter. When vividness is sufficiently low, it can give one reason to doubt the epistemic basis of the mental image and thereby act as a defeater. This account has important implications for theorizing about the epistemic roles of memory, imagination, mental imagery, and phenomenal consciousness. (shrink)

There are several important arguments in metaethics that rely on explanatory considerations. Gilbert Harman has presented a challenge to the existence of moral facts that depends on the claim that the best explanation of our moral beliefs does not involve moral facts. The Reliability Challenge against moral realism depends on the claim that moral realism is incompatible with there being a satisfying explanation of our reliability about moral truths. The purpose of this chapter is to examine these and related arguments. (...) In particular, this chapter will discuss four kinds of arguments – Harman’s Challenge, evolutionary debunking arguments, irrelevant influence arguments, and the Reliability Challenge – understood as arguments against moral realism. The main goals of this chapter are (i) to articulate the strongest version of these arguments; (ii) to present and assess the central epistemological principles underlying these arguments; and (iii) to determine what a realist would have to do to adequately respond to these arguments. (shrink)

Artificial intelligence (AI) is expected to revolutionise the practice of medicine. Recent advancements in the field of deep learning have demonstrated success in variety of clinical tasks: detecting diabetic retinopathy from images, predicting hospital readmissions, aiding in the discovery of new drugs, etc. AI’s progress in medicine, however, has led to concerns regarding the potential effects of this technology on relationships of trust in clinical practice. In this paper, I will argue that there is merit to these concerns, since AI (...) systems can be relied on, and are capable of reliability, but cannot be trusted, and are not capable of trustworthiness. Insofar as patients are required to rely on AI systems for their medical decision-making, there is potential for this to produce a deficit of trust in relationships in clinical practice. (shrink)

I present an intractable puzzle for the currently popular view that belief is weak—the view that expressions like ‘S believes p’ ascribe to S a doxastic attitude towards p that is rationally compatible with low credence that p. The puzzle concerns issues that arise on considering beliefs in conditionals. I show that proponents of weak belief either cannot consistently apply their preferred methodology when accommodating beliefs in conditionals, or they must deny that beliefs in conditionals can be used in reasoning.

I draw on neurobiological evidence to defend the rationalist thesis that moral judgments are essentially dependent on reasoning, not emotions (conceived as distinct from inference). The neuroscience reveals that moral cognition arises from domain-general capacities in the brain for inferring, in particular, the consequences of an agent’s action, the agent’s intent, and the rules or norms relevant to the context. Although these capacities entangle inference and affect, blurring the reason/emotion dichotomy doesn’t preferentially support sentimentalism. The argument requires careful consideration of (...) the empirical evidence (from neuroimaging to psychopathology) and philosophical analysis of the commitments of rationalism versus sentimentalism in ethics. (shrink)